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I. Iwe

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Open access Jul 2026

RAPID: evaluation of Cas12a protospacer nicking and chimeric reporters for PAM-independent RNA and DNA diagnostics

RAPID (RNA/DNA Advanced chimeric, PAM-independent, Integrated Nicking, Diagnostics), a nick-tuned, PAM-duplex-mediated platform for PAM-independent RNA and DNA detection and applies it to detect single-point mutations in ssDNA and RNA substrates, a challenge for traditional Cas12 and Cas13 systems.

I. Iwe, Frank X. Liu, A. Corsano et al. · 0 citations
Open access Jul 2026

CRISPR RNA-independent activation of Cas12a

It is shown that short RNAs can directly occupy the canonical crRNA-binding channel and trigger a catalytically competent trans cleavage state in the absence of PAM recognition or canonical R-loop formation.

I. Iwe, S. Singh, K. Guan et al. · 0 citations
Open access Jul 2026

Minimal Data · Maximal Insight (MDMI): A Structure-guided Pipeline for Discovering Functional Alternatives in Peptide-Protein Interfaces

Minimal Data Maximal Insight (MDMI), a two-stage structure-guided computational pipeline that designs functional peptide variants using only a small, annotated dataset, demonstrates that structure-informed pipelines can uncover remote functional sequence space from minimal data.

P. Bayat, Spencer J. Perkins, Sebastian Clancy et al. · 0 citations