Open access
Jul 2026
Decreased cerebral metabolic rate of oxygen (CMRO2) is associated with increased tau deposition in Alzheimer's disease
Transgenic Alzheimer's (AD) mouse models and post mortem studies have shown that tau pathology disrupts the mitochondrial electron transport chain and results in mitochondrial damage and synaptic dysfunction. We assessed whether magnetic resonance imaging (MRI)‐derived measures of oxygen metabolism, oxygen extraction f...
Hang-Wei Zhuang, Liang-Dong Zhou, X. Wang et al.
· Alzheimer's & Dementia · 0 citations