Open access
Decreased cerebral metabolic rate of oxygen (CMRO2) is associated with increased tau deposition in Alzheimer's disease
Hang-Wei Zhuang
Liang-Dong Zhou
X. Wang
E. Tanzi
Yi Li
P. Spincemaille
I. Kovanlikaya
Thanh D. Nguyen
Yi Wang
G. Chiang
Medicine
Abstract
Transgenic Alzheimer's (AD) mouse models and post mortem studies have shown that tau pathology disrupts the mitochondrial electron transport chain and results in mitochondrial damage and synaptic dysfunction. We assessed whether magnetic resonance imaging (MRI)‐derived measures of oxygen metabolism, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO2) were associated with tau deposition in vivo.