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İ. Özdemir

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Open access Sep 2026

Multi-Mechanistic Hepatoprotective Effects of Montelukast Against Doxorubicin-Induced Liver Injury in Rats

This study aimed to demonstrate the oxidative damage induced by DOX in liver tissue at the biochemical, histological, and molecular levels and to evaluate the protective effects of Montelukast (ML) on this damage.

İ. Özdemir, S. Çakına, L. C. İrkin et al. · 0 citations
Open access Sep 2026

The Effect of Resveratrol in Alleviating Ovarian Tissue Damage in Cadmium-Induced Rats

Cadmium (Cd) exposure leads to severe histological damage (follicular atresia, granulosa cell degeneration) and increased oxidative stress in rat ovarian tissue. This study investigates the protective potential of resveratrol (RES) against these toxic effects.Histologically, RES treatment significantly mitigated Cd-ind...

Yasemin Afşin, İ. Özdemir, Suat Cakina et al. · 0 citations
Open access Oct 2026

THE EFFECT OF BOSWELLIC ACID ON ROS PRODUCTION AND CASPASE-DEPENDENT APOPTOTIC PROCESSES IN SUPPRESSION OF HELA CELL GROWTH

Objective: Boswellic acid (BA), a pentacyclic triterpenoid derived from Boswellia species, has attracted attention for its anti-inflammatory and anticancer properties. This study investigated the anticancer effects of BA in human cervical cancer HeLa cells and explored the underlying molecular mechanisms.Methods: Cell...

İ. Özdemir, Yasemin Afşin, Ş. Öztürk · 0 citations
Open access Sep 2026

Rosmarinic Acid Enhances Doxorubicin Activity in MDA-MB-231 Cells: Associations with Intracellular Oxidative Stress, Mitochondrial Dysfunction, and Apoptosis

The RA + DOX combination showed synergistic cytotoxic activity in MDA-MB-231 cells, accompanied by increased intracellular oxidative activity, mitochondrial membrane depolarisation, apoptosis, cell-cycle perturbation, and changes in proliferation-related gene expression, which indicates associated cellular responses bu...

Coşkun Orhaner, M. Tuncer, İ. Özdemir · 0 citations
Open access Jul 2026

Rosmarinic Acid Sensitizes Ovarian Cancer Cells to Gemcitabine Through Oxidative Stress-Associated Apoptotic and Antiproliferative Responses

It is suggested that RA may enhance the anticancer activity of Gem in ovarian cancer cells through mechanisms associated with oxidative stress, apoptosis, and proliferation-related signaling pathways under both monolayer and 3D culture conditions.

Coşkun Orhaner, M. Tuncer, İ. Özdemir · 0 citations
Open access Jul 2026

Thymoquinone Potentiates Docetaxel-Induced Antitumor Activity with the Involvement of ROS and PI3K/AKT Pathway Modulation in Triple-Negative Breast Cancer Cells

The TQ + DTX combination demonstrated synergistic cytotoxicity and significantly increased apoptotic cell death compared with either monotherapy, providing evidence supporting further preclinical investigation of the TQ + DTX combination as a promising therapeutic strategy for triple-negative breast cancer.

Aylin Orhaner, M. Tuncer, İ. Özdemir · 0 citations

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