I. Sapaev

Graphene quantum dot-integrated anodes for lithium-ion batteries: electronic structure, interphase evolution, and multiscale design

Graphene quantum dots (GQDs) have emerged as multifunctional nanoscale components for lithium-ion battery anodes, yet their reported benefits are often interpreted without clearly separating intrinsic storage activity from interfacial, conductive, and architectural effects. This review develops a multiscale framework f...

Micro-Scale Strengthening Evolution in ARB-Processed Al/Al-TiB 2 Layered Laminates

Multilayer metal–ceramic laminates produced through severe plastic deformation have become an effective route for achieving high strength while maintaining reasonable ductility. In this study, Al/Al–TiB 2 layered sheets were manufactured using accumulative roll bonding (ARB) combined with intermediate high-temperat...

Integrating resting-state functional connectivity, mismatch negativity, and auditory steady-state responses reveals convergent neurophysiological biomarkers of schizophrenia

AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.

Gen silencing studies demonstrate that AEG-1 knockdown reduces proliferation, promotes apoptosis, and enhances sensitivity to chemotherapeutic agents such as cisplatin, doxorubicin, and temozolomide, and support its potential as a target for combinatorial therapeutic strategies to improve outcomes in aggressive brain a...

Exosome-Loaded Thermoresponsive Hydrogels for Tissue Regeneration: Design Principles, Delivery Mechanisms, and Translational Challenges

The article critically analyzes methods for exosome isolation, loading strategies into hydrogel matrices, and essential characterization techniques to ensure vesicle integrity and predict in vivo performance, and highlights the compelling therapeutic efficacy of this synergistic platform across diverse regenerative app...

Decellularized extracellular matrix bioinks through a polymer engineering lens: tissue-source-dependent macromolecular architecture, crosslinking chemistry, rheological behavior, and 3D bioprinting performance.

A polymer engineering perspective provides a more mechanistically useful basis for dECM bioink design than biological fidelity alone, and matching tissue-specific matrix composition, crosslinking architecture, rheological behavior, and printing parameters is essential for advancing dECM-based constructs toward clinical...

Machine learning-enhanced fluorescence signal processing of carbon quantum dots for high-accuracy chemical sensing

A comprehensive analysis of ML-driven methodologies for denoising, spectral decomposition, feature extraction, and high-accuracy classification in CQD fluorescence systems shows how ML enables ultra-low-level analyte detection, interpretable photophysical modeling, and real-time intelligent sensing across chemical and...

SIRT1 deacetylates GAPDH to drive microglial glycolysis and neuroinflammation.

SIRT1–GAPDH signaling represents a post-translational axis linking sirtuin activity directly to glycolytic enzyme function, distinct from SIRT1's traditional transcriptional roles and serving as a viable molecular checkpoint in microglial immunometabolism.