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Author

I. Songailienė

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Review Sep 2026

Building CRISPR immunity: evolution and mechanisms of spacer acquisition.

CRISPR-Cas systems in prokaryotes serve as adaptive immune systems that neutralize phage infections through RNA-guided nucleases. Immunization is achieved during the adaptation stage through Cas1-Cas2 integrase-mediated insertion of short foreign DNA snippets, termed spacers, into a CRISPR array in the host genome. Thi...

Ugne Gaizauskaite, I. Songailienė, G. Sasnauskas et al. · 0 citations
#protein folding Open access Sep 2026

Piercing mechanism in the minimal contractile tail of bacteriophage P2

A previously undescribed fold is identified in the head-to-tail adaptor, which mediates the transition from 12-fold portal symmetry to sixfold tail symmetry through interlocking β-strand “handshake” interactions and support a distinct model of contractile tail activation and expand the known architectural diversity of...

Victor Klein-Sousa, M. Šiborová, A. Roa-Eguiara et al. · 0 citations

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