I. Ullah

Techniques for Accelerating the Understanding of PROTAC-Based Ternary Complex.

Mechanism of Qilu Buxue granules in alleviating chemotherapy-induced leukopenia: Insights from network pharmacology, integrated omics, and experimental validation.

ETHNOPHARMACOLOGICAL RELEVANCE Leukopenia is a prevalent side effect of cancer chemotherapy, characterized by fever, fatigue, weakness and a significantly elevated risk of life-threatening infection. Qilu buxue granules (QBG) are clinically utilized to mitigate cyclophosphamide-induced leukopenia (CTX-IL), but the prec...

In-silico Identification of Cyclic Peptide Inhibitors for A42r Profilin-like Protein from Monkeypox Virus.

The objective of the present study was to identify cyclic peptides CycPept_3468 and CycPept_4348, which showed excellent inhibitory activity against the MPXV A42R profilin-like protein, indicating their potential efficacy as antiviral drugs.

Drug-likeness defects drive carrier-free cyanine-PROTAC self-assembly for tumor-specific protein degradation.

A versatile supramolecular strategy that directly addresses the long-standing delivery challenges of PROTACs and advances precise, controllable oncological therapy is established.

Exploring the role of nature-based solutions for climate adaptation in the agriculture sector

Climate change impacts are more severe and frequent in countries vulnerable to climate. Evidence indicates that Nature-based solutions (NbS) are widely used as cost-effective and sustainable adaptation strategies; however, their effectiveness varies across ecological, institutional, and socio-economic contexts. Our und...

A Tissue-Homologous Keratin-PBA Hydrogel Integrating Rationally Designed Nanomicelles Enables Microenvironment-Adaptive Repair of Chronic Diabetic Wounds.

A tissue-homologous, intelligently adaptive platform integrating intrinsic regenerative bioactivity with glucose-responsive therapeutic adaptability is presented, as evidenced by rapid wound closure, enhanced M2 macrophage polarization, robust neovascularization, improved collagen remodeling, and increased granulation...