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I. Vorobiev

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#protein folding Open access Aug 2026

Stable Constitutive BiP Expression Prolongs Late-Stage GLP-1–Fc Accumulation in CHO Cells

Stable constitutive expression of host-derived BiP was associated with prolonged late-stage GLP-1–Fc accumulation in the producer population examined, and these kinetics are compatible with a model in which the timing of ER chaperone supply influences the maintenance of productive output.

R. R. Shaifutdinov, Fedor A. Krukov, Anastasia S. Samok et al. · 0 citations
#protein folding Open access Aug 2026

DTT-Induced Transcriptome Profiling Reveals Divergent ER Proteostasis and Stress-Adaptation Programs in CHO-S/HB8 and CHO-4BGD/DUL Producer Clones

The producers occupy distinct ER-proteostasis states, and DUL mounts a broader, but not uniformly stronger, canonical UPR response to reductive ER stress.

N. Orlova, N. A. Potapova, R. R. Shaifutdinov et al. · 0 citations