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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Isaac Fianu

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Open access Sep 2026

Transcription pause and elongation regulators mediate somatic hypermutation.

Somatic hypermutation (SHM) creates point mutations in the variable regions of immunoglobulin genes in activated B cells to support antibody affinity maturation1. SHM is initiated by activation-induced deaminase (AID), and the single-stranded DNA substrate of this cytosine deaminase is thought to arise during RNA polym...

Li-Zhen Wu, A. D. Yadavalli, Caillan C. McAuliffe et al. · 1 citation
Review Jul 2026

Regulation of RNA transcript elongation in metazoans and its relevance to disease.

The highly orchestrated interactions between elongating Pol II and co-transcriptional RNA-processing factors are discussed, revealing that the splicing factor U1 small nuclear ribonucleoprotein (U1 snRNP) directly stimulates productive elongation.

Claudia A. Mimoso, Isaac Fianu, Karen Adelman · 2 citations

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