AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
TL;DR
The highly orchestrated interactions between elongating Pol II and co-transcriptional RNA-processing factors are discussed, revealing that the splicing factor U1 small nuclear ribonucleoprotein (U1 snRNP) directly stimulates productive elongation.
A current view of the elongation phase of Pol II is provided, focusing on mammalian cells, and the increasing complexity of the mechanisms that control transcription elongation is described.
This Review focuses on transcription by RNA polymerase II (Pol II) and discusses the integrated roles of the universal promoter scaffold factor TFIID, the transcription co-activator Mediator and the epigenetic status of the +1 nucleosome.
These findings establish ECAS as a chromatin-associated assembly that couples productive elongation with RNA processing and establishes Aqr as a highly expressed cell that profoundly impairs leukemia initiation, maintenance, and leukemia stem cell function in MLL-rearranged leukemia.
This Review summarizes mechanistic and conceptual aspects of Pol II termination, focusing primarily on studies in metazoans and incorporating insights from yeast where relevant, and discusses how termination interfaces with RNA processing, export and nuclear decay pathways to guide RNA fate decisions.
It is proposed that MraW modification of 16S rRNA enhances translation efficiency in general, and that specific transcripts have evolved structural features that fine-tune protein levels that may be prevalent in bacteria which exhibit uncoupled transcription and translation.
This study shows that native Pol II transcription complexes are isolated directly from Drosophila melanogaster embryos by using a robust one-step affinity purification and by using cryo-EM resolve multiple functional states of the Pol II transcription complex and nucleosome.
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