This Review summarizes mechanistic and conceptual aspects of Pol II termination, focusing primarily on studies in metazoans and incorporating insights from yeast where relevant, and discusses how termination interfaces with RNA processing, export and nuclear decay pathways to guide RNA fate decisions.
This Review focuses on transcription by RNA polymerase II (Pol II) and discusses the integrated roles of the universal promoter scaffold factor TFIID, the transcription co-activator Mediator and the epigenetic status of the +1 nucleosome.
Genes transcribed by the RNA polymerase (Pol) III of yeast are mostly found at sites of high transcription, genomic fragility, and replication fork stalling. Transcription terminator–dependent facilitated recycling of Pol III on naked DNA templates boosts transcription in vitro; its operability in vivo is not known. Re...
Vinesh Vinayachandran, Yatendra Kumar, S. Shivaswamy et al.· Science Advances· 0 citations
An updated framework for understanding replication timing as a key layer of genome regulation is provided, with emphasis on chromatin accessibility, histone modifications and variants, transcriptional regulators, and higher-order genome topology.
Anne Soeding, Lia Willerding, Lea Riemann et al.· Biological chemistry· 0 citations
Phosphorylation plays a central role in coordinating transcription with pre-mRNA maturation, yet the mechanistic understanding of how transcription is regulated by phosphorylation remains limited. The PP1 phosphatase removes Cdk9-dependent phosphorylation of Pol II and Spt5, triggering transcription termination. Here...
Alex Au, Abigail Southers, Krzysztof Kuś et al.· Nature Communications· 1 citation
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