TL;DR
This Review focuses on transcription by RNA polymerase II (Pol II) and discusses the integrated roles of the universal promoter scaffold factor TFIID, the transcription co-activator Mediator and the epigenetic status of the +1 nucleosome.
This Review summarizes mechanistic and conceptual aspects of Pol II termination, focusing primarily on studies in metazoans and incorporating insights from yeast where relevant, and discusses how termination interfaces with RNA processing, export and nuclear decay pathways to guide RNA fate decisions.
The +1 nucleosome has emerged as a key regulator of eukaryotic transcription, but how it controls transcription initiation remains poorly understood. Here we reconstitute transcription through the +1 nucleosome using eleven purified yeast factors: RNA polymerase II (Pol II), the six general transcription factors (GTFs)...
An updated framework for understanding replication timing as a key layer of genome regulation is provided, with emphasis on chromatin accessibility, histone modifications and variants, transcriptional regulators, and higher-order genome topology.
These findings establish ECAS as a chromatin-associated assembly that couples productive elongation with RNA processing and establishes Aqr as a highly expressed cell that profoundly impairs leukemia initiation, maintenance, and leukemia stem cell function in MLL-rearranged leukemia.
TTF2 restrains RNA Polymerase I reactivation at mitotic exit, and its loss triggers premature rRNA synthesis and nucleolar fragmentation.
Transcription involves initiation, pausing, elongation, and termination. Suppressor of Ty5 (SPT5) regulates promoter-proximal pausing and elongation, but how it orchestrates both steps during dynamic developmental changes in gene expression remains unclear. Here, using rapid optogenetic depletion in Drosophila embryos,...
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