Author

Yan-Hui Xu

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Sep 2026

IGF2 acts downstream of Hippo signaling to regulate organ growth and restore liver regeneration in aging.

Precise regulation of organ size is essential for proper function, yet the underlying logic remains unclear. Here, we identify a Hippo-IGF2 signaling axis as a regulator of organ growth. During mouse liver development, Igf2 is highly expressed in fetal and neonatal hepatocytes to fuel rapid growth but is directly silen...

Zhen-Xing Zhong, Ru-Xin Jin, Yi-Ting Zhong et al. · Cell Stem Cell · 1 citation

Review Sep 2026

The molecular basis of transcription initiation by RNA polymerase II.

This Review focuses on transcription by RNA polymerase II (Pol II) and discusses the integrated roles of the universal promoter scaffold factor TFIID, the transcription co-activator Mediator and the epigenetic status of the +1 nucleosome.

Xi-Zi Chen, Yan-Hui Xu · Nature reviews. Molecular ce... · 2 citations