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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Karen Adelman

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Open access Sep 2026

GPCR antagonism via rewiring of receptor trafficking and degradation

A novel strategy for functional GPCR antagonism via bispecific antibody-mediated endocytosis and lysosomal degradation is reported via bispecific antibody-mediated endocytosis and lysosomal degradation, establishing induced endocytosis and rewiring protein trafficking as a new paradigm for therapeutic GPCR modulation.

Kaitlin Rhee, L. Shue, Akimasa Adachi et al. · 1 citation
Review Jul 2026

Regulation of RNA transcript elongation in metazoans and its relevance to disease.

The highly orchestrated interactions between elongating Pol II and co-transcriptional RNA-processing factors are discussed, revealing that the splicing factor U1 small nuclear ribonucleoprotein (U1 snRNP) directly stimulates productive elongation.

Claudia A. Mimoso, Isaac Fianu, Karen Adelman · 2 citations

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