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Isaac S. Chan

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Open access Aug 2026

Tumor control of lysosomal acidification promotes lipoprotein assimilation and ferroptosis resistance

Lysosomes are acidic organelles that fuel cancer progression by facilitating nutrient acquisition and metabolic adaptation, yet the determinants through which cancer cells sustain specialized lysosomal functions are not fully delineated. Notably, assimilation of dietary antioxidants within lipoproteins, a lysosome-depe...

Renfei Wu, Sheng-Chieh Hsu, Lingjie Sang et al. · 0 citations
Review Open access Aug 2026

CDK4/6 Inhibitors in Breast Cancer Therapy: Mechanisms, Resistance, and Emerging Opportunities

Ongoing studies evaluating CDK2 inhibitors, CDK4-selective agents, immunotherapy combinations, and circulating tumor DNA (ctDNA)-guided strategies aim to further refine treatment sequencing and improve long-term outcomes in HR+/HER2- breast cancer.

Luise Chinea, C. Hauer, Khushboo Pal et al. · 0 citations

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