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Author

Ivan R. Corrêa

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Open access Sep 2026

Cold-adapted RNA polymerase from Pseudomonas phage Njord improves synthesis of therapeutic mRNA

A natural homolog of T7 RNA polymerase, Njord RNA polymerase, is reported on, which supports high-yield RNA synthesis at substantially lower temperatures and is a promising candidate for improving the performance and scalability of mRNA therapeutics.

D. Nye, Tien-Hao Chen, Jennifer L. Curcuru et al. · 0 citations
Open access Aug 2026

Coronavirus NSP14 drives internal m7G modification to rewire host splicing and promote viral replication

Using SARS-CoV-2 infection models, it is shown that viral replication is associated with increased cellular m7G signal, supporting the relevance of this pathway during infection and suggesting that NSP14-induced m7G modification may contribute to the remodeling of host gene expression during coronavirus infection.

Ensueño Esmeralda Sáenz Altamirano, Chien-Hsin Huang, Yueh-Lin Tsai et al. · 0 citations

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