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J. Guyette

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#protein folding Open access Sep 2026

A Single Amino Acid in the A2 Linker of Cholera Toxin Affects the Efficiency of Toxin Disassembly and Resulting Toxicity

The collective data uncover the critical role of D229 in toxin folding and structural dynamics, which in turn impacts toxin potency through effects on the efficiency of PDI-driven toxin disassembly.

F. Kersten, Natalia Mojica, Albert Serrano et al. · 0 citations
Aug 2026

Full-length premembrane protein is not required for mature Zika virus particle assembly.

Assembly of flaviviruses such as Zika virus (ZIKV), dengue virus, and West Nile virus in the host cell endoplasmic reticulum is driven by the structural envelope (E) and premembrane (prM) proteins. The formation of an infectious virion requires cleavage of prM by the host furin protease during a maturation step that is...

Kimberly A. Dowd, Michelle Schroeder, Egan Sanchez et al. · 0 citations

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