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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

J. Law

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Open access Aug 2026

A Gut-Specific Bispecific Combining MAdCAM-1 Blockade and IL-22 Signaling to Halt T-Cell Inflammation and Promote Mucosal Restoration

A protein bispecific composed of a human IgG4-Fc domain displaying an antagonistic anti-human MAdCAM-1 single chain (sc)-Fv and a human interleukin (IL-)22 provides a localized dual-mechanism strategy for restoring intestinal immune homeostasis.

J. D. Sanchez Vasquez, A. Sparkes, N. Asokumar et al. · 0 citations

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