Author

J. Leverenz

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#gene editing Open access Oct 2026

Alzheimer's disease target and drug discovery by leveraging multiomics and electronic health data.

Despite prolific genomic data from individuals with Alzheimer's disease (AD), translation into treatments has lagged. Here we applied Mendelian randomization to multiple AD genome-wide association studies and functional multiomics datasets to nominate druggable targets, identifying 19 targets for individuals of Europea...

Yuan Hou, Yi-Chen Li, Peng-Yue Zhang et al. · Nature Neuroscience · 0 citations

Open access Sep 2026

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

CSF proteomics revealed stronger APOEε4 and amyloid‐associated analyte signatures than plasma, and CSF inflammatory signaling, particularly eotaxin‐1, may serve as a correlate of longitudinal cognitive decline in cognitively normal older adults at risk for AD.

Jagan A. Pillai, Audrey Zhu, Chun-Xuan Ma et al. · Annals of Clinical and Trans... · 0 citations

Open access Aug 2026

Plasma inflammatory biomarker associations with Alzheimer's disease clinical stage and CSF biomarkers: evaluation of sex effects

The findings identify a group of peripheral inflammatory markers associated with AD pathology and suggest that some of these relationships may vary by sex, warranting larger studies to clarify the role of sex in AD pathobiology.

Rene Coig, Lavanya Jain, M. Khrestian et al. · medRxiv · 0 citations