Author

J. Merl-Pham

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Open access Sep 2026

Combinatorial targeting of the miR-379/miR-410 cluster normalizes glucose and lipid homeostasis in male models of diabetes and obesity

Non-coding RNAs from the Dlk1-Dio3 locus are critical for the maturation of metabolic tissues in early stages of postnatal development; however, their role in the mature organs remains elusive. Herein, we show that microRNAs from the miR-379/miR-410 cluster are robustly upregulated in livers of subjects with obesity an...

Manuel Gil-Lozano, E. Simoes, Mo-Ya Wu et al. · Nature Communications · 0 citations

#gene editing Open access Sep 2026

Creating bottom-up RNA transfer vehicles from synthetic protein assemblies.

This work demonstrates how proteins created by generative artificial intelligence can be harnessed for the rational engineering of RNA transport systems with the desired properties by overcoming the limitations of natural protein diversity.

Maren Kirstin Schuhmacher, Christoph Gruber, Christopher M. R. Lang et al. · Nature · 1 citation