Dynamic phosphorylation of DGCR8 regulates embryonic stem cell differentiation and microprocessor function
The Microprocessor complex, minimally composed of DROSHA and DGCR8, is ubiquitously required for microRNA biogenesis. It also regulates the balance between pluripotency and differentiation through mRNA alternative splicing and mRNA cleavage. However, how these various activities are regulated remains incompletely und...
K. Leong, Lawrence Mok, Karen Gu et al.
· Frontiers in Cell and Develo... · 0 citations