Structural Plasticity and Ligand Promiscuity of CYP3A4 Revealed by Cryo-EM
Cytochrome P450 3A4 (CYP3A4) metabolizes roughly half of all marketed drugs, and its inhibition can cause clinically significant drug-drug interactions. The enzyme accommodates chemically diverse ligands, making binding modes and metabolic outcomes difficult to predict. Previous X-ray crystallography efforts have lever...
Anna K. Orta, Jan-Hannes Schäfer, G. Correy et al.
· bioRxiv · 0 citations