Author

J. Perera-Bel

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Open access Aug 2026

Comparing trajectories of cognitive functioning in treatment-resistant and non-resistant depression: a multicentre linear mixed-effects analysis.

BACKGROUND Impaired cognitive functioning is a severe symptom in major depressive disorder (MDD). Recent evidence suggests it may be a central characteristic in its treatment resistant form (TRD), potentially constituting a clinical marker for treatment resistance and a target amenable to intervention. To date, cogniti...

V. T. Wahner, T. Lange, Inga Stonner et al. · Journal of Affective Disorde... · 0 citations

Review Open access Sep 2026

Somatic likelihood tiering: an interpretable post-calling triage protocol for tumor-only whole-exome variant review

SLT provides an auditable tumor-only WES review queue, not a substitute for matched-normal sequencing, independent orthogonal validation, or definitive somatic classification, and is the primary calibration frame.

Konrad Stawiski, S. Kamran, J. Perera-Bel et al. · Briefings in Bioinformatics · 0 citations

Open access Aug 2026

RERE and the Mediator complex cooperate with EWSR1::FLI1 in the reprogramming of Translation and Alternative Splicing, the latter being a therapeutically targetable vulnerability in Ewing sarcoma

The identification of the splicing factor RBM39 as a vulnerability in ES is supported by the extraordinary sensitivity of these tumors to monotherapy with RBM39 degrader indisulam, highlighting the potential of this approach as a novel and promising therapeutic strategy for Ewing sarcoma.

Irene Cuervas, Sophie Bonnal, Evelyn Andrades et al. · bioRxiv · 0 citations