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RERE and the Mediator complex cooperate with EWSR1::FLI1 in the reprogramming of Translation and Alternative Splicing, the latter being a therapeutically targetable vulnerability in Ewing sarcoma

Irene Cuervas Sophie Bonnal Evelyn Andrades Silvia Mateo-Lozano María Sánchez-Jiménez P. Berenguer-Molins Ariadna Acedo-Terrrades M. Bódalo-Torruella J. Perera-Bel Ramón Gimeno Mònica Roldán E. Prada Juan Valcárcel Jaume Mora Inmaculada Hernández-Muñoz

Aug 2026 · bioRxiv · 0 citations

Biology

TL;DR

The identification of the splicing factor RBM39 as a vulnerability in ES is supported by the extraordinary sensitivity of these tumors to monotherapy with RBM39 degrader indisulam, highlighting the potential of this approach as a novel and promising therapeutic strategy for Ewing sarcoma.

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