Author

Mònica Roldán

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Open access Oct 2026

Diffusion-Based Inference for Heterogeneous Multichannel Fluorescence Imaging

Fluorescence microscopy is a central tool in biomedical image analysis, but its practical use is often constrained by incomplete and heterogeneous data. This is especially true in rare disease research, where patient cohorts are small, biological material is limited, and complex study designs frequently yield images wi...

I. Georvasilis, Marcos Frías Nestares, C. Badosa et al. · bioRxiv · 0 citations

Open access Aug 2026

RERE and the Mediator complex cooperate with EWSR1::FLI1 in the reprogramming of Translation and Alternative Splicing, the latter being a therapeutically targetable vulnerability in Ewing sarcoma

The identification of the splicing factor RBM39 as a vulnerability in ES is supported by the extraordinary sensitivity of these tumors to monotherapy with RBM39 degrader indisulam, highlighting the potential of this approach as a novel and promising therapeutic strategy for Ewing sarcoma.

Irene Cuervas, Sophie Bonnal, Evelyn Andrades et al. · bioRxiv · 0 citations