Author

J. Strickler

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Open access Oct 2026

Multimodal Immune Profile Score (IPS) as a Pan-Cancer Biomarker for Stratifying Outcomes of Immune Checkpoint Inhibitor Benefit in Microsatellite Stable Colorectal Cancer and Rare Solid Tumors

Background Immune checkpoint inhibitor (ICI) therapies have revolutionized oncology, but identifying patients who benefit remains a challenge, particularly in populations where ICIs are not the standard of care, including microsatellite stable colorectal cancer (MSS CRC) and rare solid cancers. We evaluated real-world...

M. Ting-Lin, E. Antonarakis, X. Wang et al. · medRxiv · 0 citations

#protein folding Open access Aug 2026

The KRASG12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

Using stability-based proteomics, this study shows how protein folding stability-based profiling can expand the actionable target landscape of small molecules beyond canonical covalent interactions, uncovering noncovalent off-targets that may underlie response heterogeneity and treatment-associated toxicity.

Ssu-Yu Chen, Y. Zou, Jianli Wu et al. · bioRxiv · 0 citations