Corynebacterium glutamicum serves as a pivotal industrial platform organism, accounting for an annual global amino acid output of several million tons. Elucidating its adaptive mechanisms under diverse environmental perturbations during high-density fermentation is fundamental to advanced metabolic engineering and st...
Yu-Jie Wang, Man-Man Han, Pei-Bin Qin et al.· Journal of Proteome Research· 0 citations
Adenosine triphosphate (ATP) is the primary energy currency of microbial cells and a system-wide signal coordinating metabolism, gene expression and cellular physiology. Yet, ATP homeostasis is often treated implicitly in strain and process engineering. This review presents an ATP-centered framework for microbial cell...
Hao-Ran Ding, Meng-Tian Lu, Hong-Yu Zhang et al.· Critical Reviews in Biotechn...· 0 citations
A set of fault diagnosis and predictive maintenance system driven by digital twin driven by digital twin is constructed, and a decision-making model aiming at minimizing maintenance cost is constructed to optimize maintenance strategy.
Ji-Bing Sun, Yun-Ming Zhang, Jinpeng Gong et al.· International Conference on...· 0 citations
Carbon catabolite repression (CCR) is a widespread regulatory strategy across diverse microorganisms that prioritises the utilisation of preferred carbon sources. In industrial bioprocesses, however, CCR-mediated substrate hierarchy can delay the utilisation of secondary carbon sources in mixed feedstock, thereby exten...
Meng-Tian Lu, Hao-Ran Ding, Hong-Yu Zhang et al.· Synthetic and Systems Biotec...· 0 citations
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