Author

Jizhong Zou

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#gene editing Open access Oct 2026

Impacts of different SETD1A mutations and genetic backgrounds on human induced pluripotent stem cell-derived hippocampal neurons

Human induced pluripotent stem cells (hiPSCs) provide a translational platform to interrogate the impact of genetic risk factors for various disorders on human biology. It has been a common practice to engineer premature stop codons to model predicted loss-of-function mutations using isogenic hiPSCs, yet effects of mut...

Yan Hong, Ting Zhao, Qian Yang et al. · bioRxiv · 0 citations

Open access Sep 2026

Cellular modifiers of TDP-43 phase transition and cytoplasmic aggregation

RNA-binding protein TAR DNA-binding protein 43 (TDP-43) can form liquid-like nuclear assemblies whose phase behavior is thought to influence its aggregation propensity and neurotoxic activity. The mechanisms that govern the liquid-to-solid phase transition of TDP-43 remain poorly defined. Here, we combined chemical and...

Natalie Chin, Qi Zhang, Ji-Zhong Zou et al. · eLife · 0 citations

Open access Aug 2026

Establishment of human induced pluripotent stem cell lines and isogenic gene-corrected controls from three patients with prolidase deficiency.

These iPSC lines are valuable models to help investigate the pathomechanism of prolidase deficiency and are reprogrammed into induced pluripotent stem cell (iPSC) lines and additionally generated isogenic controls using CRISPR-Cas9 genome editing.

R. Suri, Kevin Emmerich, Sahana Manohar-Sindhu et al. · Stem Cell Research · 0 citations