Author

Jia-Feng Liu

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Aug 2026

Pre-existing antibiotic tolerance facilitates plasmid-mediated carbapenem resistance evolution in clinical Klebsiella pneumoniae

Clinical antibiotic tolerance is identified as a pre-existing, MIC-hidden phenotype that can facilitate plasmid-mediated carbapenem resistance evolution in K. pneumoniae.

Wei-Li Zhang, Bo Zheng, Meng-Lan Zhou et al. · bioRxiv · 0 citations

Open access Aug 2026

Outer membrane stiffness gates multidrug tolerance

Outdoor membrane stiffness is revealed as a previously unrecognized physical basis of multidrug tolerance and modulating bacterial envelope mechanics may provide new opportunities for antimicrobial intervention, suggesting that modulating bacterial envelope mechanics may provide new opportunities for antimicrobial inte...

Nan Xiao, Bo Zheng, Jia-Feng Liu · bioRxiv · 0 citations