TL;DR
Clinical antibiotic tolerance is identified as a pre-existing, MIC-hidden phenotype that can facilitate plasmid-mediated carbapenem resistance evolution in K. pneumoniae.
Purpose Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major global public health threat due to its high-level antimicrobial resistance and limited therapeutic options. The emergence of CRKP isolates co-harboring multiple carbapenemase genes further complicates clinical management and infection control....
ABSTRACT Bacteria pose a serious threat to hosts through adaptive mutations that confer stress resistance and promote persistent colonization. Here, we describe an adaptive evolution event involving eight highly similar ST11-KL64 carbapenem-resistant Klebsiella pneumoniae (CRKP) strains, isolated from a non-infected in...
Background: Antimicrobial resistance in Klebsiella pneumoniae is a growing global health concern, with rising multidrug- and carbapenem-resistant strains narrowing treatment options. Colistin remains a last-resort agent, but plasmid-mediated mobile colistin resistance (mcr) genes threaten its efficacy through horizonta...
Background: Carbapenem-resistant Klebsiella pneumoniae (CRKP) represents a major global clinical threat driven by both clonal relatedness and horizontal transfer of antimicrobial resistance determinants. This study aimed to characterize CRKP isolates through an integrated analysis of phenotypic resistance, resistance g...
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