Author

Jia-Hao Ge

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Open access Jan 2026

Mutation‐Immune Crosstalk Contextualizes CAF‐Associated ARPC1A Programs and Cisplatin Response in Gastric Cancer

Cisplatin response in gastric cancer is shaped by malignant cell programs, stromal states, and mutation‐immune crosstalk, but the CAF subtypes linked to platinum tolerance and their epithelial effectors remain incompletely defined. We integrated single‐cell RNA sequencing, epithelial CNV‐like inference, fibroblast recl...

Deyi Lu, Fanlai Meng, Weiying Zhou et al. · Human Mutation · 0 citations

#gene editing Open access Aug 2026

Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs

Lipid nanoparticles (LNPs) are the most advanced non-viral platform for hepatic mRNA delivery, yet the functional role of helper phospholipids, particularly under repeated dosing regimens required for chronic protein replacement therapies, remains poorly understood. Here, we systematically investigated six helper phosp...

Jia-Hao Ge, Xiaochen Bo, Xinye Zhu et al. · Materials Today Bio · 1 citation