Proteostasis is essential for cellular health, with its disruption contributing to aging, neurodegeneration, and metabolic disorders. While the upstream proteotoxic stress-sensing and protein-folding mechanisms in the ER and cytosol are well studied, the transcriptional regulation of proteostasis remains incompletely u...
Syeda Kubra, Michelle Sun, William Dion et al.· PLoS Biology· 0 citations
Cisplatin is a widely used chemotherapeutic agent, but acute kidney injury (AKI) remains its dose-limiting toxicity, particularly in older patients. In recent years, dysregulated lipid metabolism has emerged as a key driver of cisplatin nephrotoxicity; however, the underlying mechanisms and their modulation across ages...
Saiya Zhu, Chen Dai, Kelly Zheng et al.· AJP - Renal Physiology· 0 citations
OBJECTIVES
This study aimed to develop KOA-Diff, a multimodal diffusion model predicting future knee radiographs for accurate, visually interpretable forecasting of knee osteoarthritis (KOA) progression.
METHODS
KOA-Diff utilizes a latent diffusion backbone and a multimodal fusion network to integrate baseline X-rays...
Dingyu Wang, Xue-Qing Yu, Xin-Wei Du et al.· Osteoarthritis and Cartilage· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
