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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Jiacheng Sun

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Review Aug 2026

Beyond necroptosis: structural determinants, context-dependent non-canonical functions, and precision therapeutic targeting of RIPK3.

Receptor-interacting protein kinase 3 (RIPK3) is classically recognized as a central executor of necroptosis, but accumulating evidence indicates that its functions extend beyond lytic cell death. RIPK3 regulates metabolic processes, inflammatory signaling, organelle homeostasis, and stress responses through both kinas...

Yun-Tian Shen, Haiyan Jiang, Jie Wang et al. · 0 citations
Review Aug 2026

The dual role of cell death in skeletal muscle homeostasis and disease: Mechanisms and therapeutic targeting.

The molecular mechanisms underlying major cell death pathways are summarized and their context-dependent roles in skeletal muscle physiology are discussed, including development, adaptation, regeneration, and aging, as well as in disease progression.

Jiahuan Gong, Hong-Yi Xu, Yun-Tian Shen et al. · 4 citations
Aug 2026

Tectorigenin protects against muscle atrophy from in vitro nutrient deprivation and in vivo denervation by activating the AMPK/SIRT1/PGC-1α pathway.

BACKGROUND AND PURPOSE The molecular mechanisms underlying denervation-induced muscle atrophy remain incompletely understood, and effective therapeutic interventions are currently lacking. Tectorigenin (TG), a natural isoflavonoid, has demonstrated antioxidant and metabolic regulatory activities. This study investigate...

Boya Liu, Fei Xue, Xingxing Fang et al. · 2 citations
Review Aug 2026

The role of m6A RNA methylation in skeletal muscle pathophysiology and its targeted therapeutic prospects.

The composition and function of the m6A modification system is summarized, with a focus on its critical roles in skeletal muscle physiology, including satellite cell fate determination, myofiber differentiation and fusion, and energy homeostasis, and the molecular mechanisms by which m6A network dysregulation contribut...

Jie Wang, Haiyan Jiang, Jiacheng Sun et al. · 1 citation
Review Open access Jul 2026

The cGAS–STING pathway in tumor immunity: dual roles, regulatory mechanisms, and precision therapeutic strategies

This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.

Haiyan Jiang, Zhanzhan Li, Xia Li et al. · 2 citations

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