Aug 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 1 citation· 126 references
Medicine
TL;DR
The composition and function of the m6A modification system is summarized, with a focus on its critical roles in skeletal muscle physiology, including satellite cell fate determination, myofiber differentiation and fusion, and energy homeostasis, and the molecular mechanisms by which m6A network dysregulation contributes to skeletal muscle diseases.
The basic concepts of m6A modification are summarized and its emerging roles in the regulation of bone metabolism are discussed, with particular focus on osteoblasts, osteoclasts, osteocytes, and bone marrow mesenchymal stem cells.
S. Kokabu, Yuan Quan· Oral Science International· 0 citations
This review focuses on the interplay between immunity and epitranscriptomics and explores the direct and indirect effects of m6A modification on T cells and highlights the pivotal role of m6A regulation in T cell biology and its potential to optimize next-generation immunotherapies.
Yumna A. Butt, Nordin D. Zandhuis, I. Foskolou· Immuno· 0 citations
This article systematically reviews the progress in the study of RNA modification in regulating the fate of skeletal muscle, focusing on the dynamic regulatory mechanisms and pathophysiological significance of N6-methyladenosine (m6A) modification in muscle differentiation, regeneration, and atrophy.
Du-Jun Chen, Mai-Lin Gan, Yu-Hang Lei et al.· Molecules· 1 citation
This review systematically summarize the functional roles of m6A regulators, including writers, erasers, and readers, in breast cancer biology and highlights the emerging clinical potential of m6A regulators as diagnostic and prognostic biomarkers, as well as therapeutic targets for overcoming drug resistance.
Zilong Chen, Chi Zhou, Zhuo-Run Song et al.· Cancer Treatment and Researc...· 0 citations
Empirical evidence elucidating how m6A regulators remodel cystine import, GPX4-dependent antioxidant defense, FSP1 signaling, lipid metabolism, iron handling, autophagy and tumor-microenvironmental communication is synthesized.
Qing-Miao Shi, Yang-Ni Li, Chao Guan· Frontiers in Cell and Develo...· 0 citations
A framework for understanding the regulatory networks of m6A-PTMs crosstalk in disease pathogenesis, development, and therapeutic response is provided, highlighting potential treatment strategies based on this interplay and suggesting future research directions.
Xinyi Li, Li-Ting Yang, Xian-Min Zhou et al.· Biochimica et Biophysica Act...· 0 citations
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