Hepatocellular carcinoma (HCC) is characterized by high heterogeneity, a complex tumor microenvironment, and multiple physiological barriers that limit conventional therapies and cause significant toxicity. Drug delivery systems (DDS), particularly nanoscale delivery systems, offer promising opportunities to overcome t...
Gui-Wen Liang, Chu-Lin Zhu, Hua-Lin Sun et al.· Drug Design, Development and...· 0 citations
Abstract The mechanosensitive ion channel Piezo1 translates physical cues from the tumor microenvironment—including extracellular matrix stiffness, fluid shear stress, and compressive forces—into intracellular calcium signals and downstream cascades, playing a pivotal role in cancer. Piezo1 exhibits pronounced tumor-ty...
Hai-Yan Jiang, Ying Liu, Fei Xue et al.· Drug Design, Development and...· 0 citations
Current mechanistic insights inspire targeted therapeutic strategies comprising α-synuclein inhibitors, mitochondrial protectants, anti-inflammatory agents, and novel cell death pathway blockers, alongside gut-brain axis interventions for PD, but these approaches face substantial challenges.
How neuroendocrine alterations drive downstream molecular mechanisms-specifically neuroinflammation, a shift in the kynurenine pathway, mitochondrial dysfunction, and impaired brain-derived neurotrophic factor (BDNF) signaling-that collectively remodel stress-related brain circuits are explored.
Xia Li, Yanbei Zhu, Ya-Nan Ji et al.· Biochemical Pharmacology· 2 citations
The composition and function of the m6A modification system is summarized, with a focus on its critical roles in skeletal muscle physiology, including satellite cell fate determination, myofiber differentiation and fusion, and energy homeostasis, and the molecular mechanisms by which m6A network dysregulation contribut...
Jie Wang, Haiyan Jiang, Jiacheng Sun et al.· Naunyn-Schmiedeberg's Archiv...· 1 citation
This review systematically elucidates the molecular activation mechanisms of the cGAS–STING pathway and its complex regulatory networks within tumors, with a particular focus on analyzing its dual functions—tumor immune surveillance versus tumor promotion—and the determining factors involved.
Haiyan Jiang, Zhanzhan Li, Xia Li et al.· Frontiers in Pharmacology· 2 citations
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