Antibiotic-resistant tuberculosis remains a major public health challenge, and rapid diagnosis of resistant infections based on genomic markers holds promise for improving time to effective treatment. However, the vast majority of clinically observed variants in resistance-associated genes remain of uncertain significa...
Mahbuba Tasmin, Shrishti Barethiya, Yu Wang et al.· bioRxiv· 0 citations
DNA is a fundamental biomolecule in eukaryotic cells, playing central roles in processes ranging from genome organization and transcription to innate immune signaling. Recent studies have revealed that DNA can undergo protein-free phase separation in the presence of divalent cations, yet the underlying molecular mechan...
The MspA nanopore platform demonstrated using the intrinsically disordered transactivation domain of tumor suppressor p53 (p53-TAD) showed that MspA can stably capture p53-TAD and resolve up to six distinct current states with frequent interconversions, revealing a rich conformational landscape.
David DeCoeur, Samantha A Schultz, Jian-Han Chen et al.· bioRxiv· 0 citations
These findings establish antibiotic-driven phase separation as a previously unrecognized mechanism to encode cellular signaling and identify antibiotic condensates as a distinct functional unit underlying drug tolerance.
Yuefeng Ma, Wen Yu, E. Moon et al.· bioRxiv· 0 citations
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