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Review Open access Sep 2026

Beyond the blood-brain barrier: humanised mice, the missing link in glioblastoma research.

Glioblastoma (GBM) remains a major challenge in neuro-oncology, associated with a high rate of mortality despite decades of intensive research and therapeutic advancements, underscoring the urgent need for innovative preclinical platforms that can more accurately recapitulate the biological and pathological features of...

Reza Shirazi Nia, Jian Lu, D. de Vega et al. · 0 citations
Aug 2026

Context-dependent promotion of epithelial-mesenchymal transition by IL-13Rα2/STAT6 signaling in colorectal cancer

It is demonstrated that IL-13Rα2 is a crucial, context-dependent signaling receptor that maintains the p-EMT state and malignant progression via the STAT6 axis, making it a precise therapeutic target for advanced, phenotypically plastic colorectal cancer.

Jian Lu, Marko Kornmann, B. Traub · 1 citation

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