Context-dependent promotion of epithelial-mesenchymal transition by IL-13Rα2/STAT6 signaling in colorectal cancer

Oncofetal reprogramming and cellular plasticity in colorectal cancer: from mechanisms to clinical translation

The conceptual boundaries and operational criteria for identifying OnF in CRC are discussed, its regulatory mechanisms, plasticity-associated phenotypes, and translational relevance are examined, and the importance of distinguishing direct evidence of OnF from evidence of related plasticity mechanisms is emphasized.

Role of epithelial-mesenchymal transition (EMT) in malignancies: current status and future prospects

Unraveling the intricate mechanisms of EMT activation in cancer will contribute to the advancement of personalized medicine and the design of more effective treatments against metastatic disease and pave the way for advancements in personalized medicine and improved treatment strategies for patients affected by EMT-rel...

miR-142-3p in cancer: intracellular tumor suppression and extracellular vesicle- mediated microenvironmental signaling

The dual intracellular and extracellular functions of miR-142-3p in cancer are summarized and its contribution to treatment sensitivity and TME interactions is highlighted.

Abstract A006: A p38α MAPK-TCF21 axis regulates pancreatic stellate cell activation and stromal reprogramming in pancreatic cancer

Pancreatic stellate cells (PSCs) are a principal source of cancer-associated fibroblasts (CAF) in pancreatic ductal adenocarcinoma (PDAC), yet the mechanisms that convert tumor-derived inflammatory cues into a persistent, CAF-like state remain poorly defined. We previously identified tumor cell-intrinsic p38α MAP...

TNIK maintains a MYC-driven partial EMT state that supports proliferation and evasion of senescence in lung squamous cell carcinoma

Context-dependent interactions between immune checkpoint and epithelial-mesenchymal transition programs shape the tumor microenvironment in esophageal squamous cell carcinoma

Findings delineate context-dependent transcriptional interactions between ICP and EMT pathways in ESCC and highlight the complexity of the tumor immune microenvironment beyond single-parameter biomarkers such as TMB.