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Open access Sep 2026

Neural Stem Cell‐Derived Extracellular Vesicles Improve CNS Delivery and Therapeutic Efficacy of Antisense Oligonucleotide in Amyotrophic Lateral Sclerosis

ABSTRACT Antisense oligonucleotides (ASOs) hold clinical promise for the treatment of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS). Yet, their efficacy is constrained by the need for invasive delivery, poor central nervous system (CNS) penetration, inefficient cellular uptake and rapid clearan...

Yao-Chao Zheng, Taylor J. Ellison, Robert Garrard et al. · 0 citations
#protein folding Preprint Sep 2026

Gel-Confined Rolling-Circle Amplification Enables Sensitive Single-Cell Proteoform Analysis

CAmp-scWB, a post-separation amplification strategy that performs rolling-circle amplification directly within the polyacrylamide gel after single-cell protein electrophoresis, enables proteoform-resolved analysis of heterogeneous cells and small extracellular vesicles.

Lu-Yao Zhao, Yan-Jun Yang, Yao-Chao Zheng et al. · 0 citations

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