Jin Zhang

Nanoscale Architecture Can Control Cellular Function.

Nanoscale protein clustering at the plasma membrane has emerged as a fundamental mechanism for organizing cellular signaling, yet how nanocluster size is actively regulated and whether architectural changes at this scale carry functional consequences remain poorly understood. Here, we used the prototypical membrane sca...

A chemigenetic endogenous Ras activity biosensor for live-cell pharmacology

Protein engineering: status report

Protein engineering appears to be entering a golden age, defined by a rapidly accelerating pace of progress, even as significant challenges in design, screening, and real-world application remain.