#gene editing
Oct 2026
Genetic and Epigenetic Manipulation Using CRISPR Techniques in Ewing Sarcoma.
M. Knott, Jing Li
· Methods in molecular biology · 0 citations
4 papers indexed here
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Sep 2026
Oncogenic fusions induce an extensive cancer-restricted cryptic proteome in Ewing sarcoma
Luuk A. Broeils, Jill Pilet, Mariia K. Koshkina et al.
· bioRxiv · 0 citations
Open access
Sep 2026
Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma
Functional experiments demonstrate that LMO7 silencing decreases clonogenicity and migratory capacity in vitro and suppresses primary tumor growth and metastatic dissemination in vivo, and illustrate how integrating functional, spatial and clinical data can uncover oncogene-driven effectors of metastasis.
Veronika Buršić, Heng Luo, C. Hénon et al.
· bioRxiv · 0 citations
Open access
Aug 2026
Functional spatial transcriptomics uncover LMO7 as a fusion-regulated and clinically relevant driver of metastasis in Ewing sarcoma
Metastatic dissemination represents the major determinant of poor clinical outcome across cancer entities. Yet, how driver oncogenes shape transcriptional programs facilitating metastasis is poorly understood. In Ewing sarcoma (EwS) – a highly aggressive pediatric bone and soft-tissue sarcoma driven by chimeric FET::ET...
Veronika Buršić, Heng Luo, C. Hénon et al.
· bioRxiv · 0 citations