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Author

Jing-Mei Cha

3 papers indexed here

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Open access Jul 2026

RNF220 safeguards meiotic synapsis and male fertility by antagonizing SYCE1 ubiquitination

The essential role of RNF220 is defined and novel molecular insights into the pathogenesis of male infertility are provided and provide novel molecular insights into the pathogenesis of male infertility.

Jing-Mei Cha, Huijuan Lin, Yingqian Xia et al. · 0 citations
Open access Jul 2026

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

The findings reveal that the RLIM–SLC7A11‐GSH signaling axis governs ferroptosis resistance in OL lineage cells, implicates this pathway in RLIM‐related neurodevelopmental disorders, and suggests GSH as a potential therapeutic strategy.

Yu-Wei Li, Hai-Jun Zhang, Jie-Ya Zhou et al. · 0 citations
#gene editing Open access Aug 2026

Nigral DJ-1 gene knockout in tree shrews can induce phosphorylated α-synuclein aggregation and all key phenotypes of Parkinson’s disease

In vivo evidence is provided supporting a model in which DJ-1 deficiency can promote key PD-like phenotypes in tree shrews, potentially involving PSer129αSyn accumulation, nigral dopaminergic neuron loss, and motor dysfunction.

Hao Li, Leyi Mei, Jing-Mei Cha et al. · 0 citations

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