Author

Jin-Jin Chen

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Open access Aug 2026

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable prognosis. Mechanistically, YTHDC1 orche...

Zheng-Hao Lai, Yi Wang, Na-Na Li et al. · Advancement of science · 0 citations

Jul 2026

Lipid Nanoparticle-Encapsulated mRNA-Targeting CD19 for B and Plasma Cell Depletion in Autoimmune Diseases 2308376

The findings suggest that mRNab-LNPs offer a promising alternative to current therapies, providing a safer, more efficient approach to treating autoimmune diseases by resetting the humoral immune system.

Yiming Zhou, Jinjin Chen, Chi-Peng Guo · Journal of Immunology · 0 citations

#gene editing Aug 2026

Lipopolymer Nanoparticle‐Mediated In Vivo CRISPR‐Cas9 Editing of Mrg15 Restores Mitochondrial Mitophagy to Alleviate Metabolic‐Associated Steatohepatitis

A liver‐targeted lipopolymer nanoparticle‐mediated gene editing platform is developed to enable in vivo disruption of Mrg15 by co‐delivery of Cas9 mRNA and Mrg15 sgRNA to identify Mrg15 as a disease‐relevant epigenetic regulator in MASH and highlight liver‐directed P64H LPNP/CRISPR delivery as a promising non‐viral str...

Zixi Zhang, Jing Liao, Ting-Feng Yu et al. · Advanced Healthcare Material... · 0 citations