Author

Jiyong Hong

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Open access Aug 2026

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Cell-type-specific opioid blockade in accumbal cholinergic interneurons abolishes morphine-reward learning without impairing analgesia and decouples morphine-evoked dopamine elevations from acetylcholine dips, suggesting pro-cholinergic strategies to limit early opioid reward acquisition.

S. Yousefzadeh, Hai-Dun Yan, Seung-Hwa Kwak et al. · Nature · 2 citations

#protein folding Open access Aug 2026

The KRASG12C Inhibitor Divarasib Stabilizes RBM39 and Antagonizes Aryl-Sulfonamide Degraders

Using stability-based proteomics, this study shows how protein folding stability-based profiling can expand the actionable target landscape of small molecules beyond canonical covalent interactions, uncovering noncovalent off-targets that may underlie response heterogeneity and treatment-associated toxicity.

Ssu-Yu Chen, Y. Zou, Jianli Wu et al. · bioRxiv · 0 citations