Author

Joanna Re

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Open access Aug 2026

Evolutionary conservation analysis reveals a primordial function of STING as a regulator of lipid metabolism via FADS2

The stimulator of interferon genes (STING) is a pivotal regulator of type I interferon (IFN) responses. Although the IFN system is confined to vertebrates, STING is present across metazoans and in some unicellular eukaryotes, suggesting involvement in distinct functions prior to vertebrate divergence. Here we explore t...

Soumyabrata Guha, Joanna Re, S. Grégoire et al. · Nature Communications · 0 citations

Aug 2026

The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.

It is reported that Casein Kinase 1 alpha operates as a bimodal regulator of the cGAS-STING pathway, and selective degradation of CK1α using molecular-glue degraders suppressed aberrant cGAS-STING-driven inflammation signaling in a chromosomally unstable triple-negative breast cancer cell line.

Jane Jardine, Marine Tarrillon, G. André-Grégoire et al. · Cell Death and Differentiati... · 0 citations