The kinase CK1α coordinates the initiation and termination of the cGAS-STING pathway.

Jane Jardine Marine Tarrillon G. André-Grégoire K. Trillet Vanessa Josso Laura Merlet Rosalie Moreau Célia Jaunasse Luc Antigny S. Marionneau‐Lambot F. Guillonneau A. Boissard Cécile Henry Joanna Re S. Barillé-Nion N. Laguette Philippe P. Juin J. Gavard N. Bidère

Aug 2026 · Cell Death and Differentiation · 0 citations · 78 references

Medicine

TL;DR

It is reported that Casein Kinase 1 alpha operates as a bimodal regulator of the cGAS-STING pathway, and selective degradation of CK1α using molecular-glue degraders suppressed aberrant cGAS-STING-driven inflammation signaling in a chromosomally unstable triple-negative breast cancer cell line.

DOI PubMed Semantic Scholar

View source

Similar papers

Review Open access Aug 2026

The cGAS/STING pathway in cancer: translating innate DNA sensing into therapeutic potential

How context determines the consequences of cGAS/STING activation in cancer is examined, emerging therapeutic strategies that modulate this pathway are reviewed, and how its antitumor potential can be maximized while minimizing systemic toxicity and immune dysregulation is discussed.

Yi Wang, J. Angulo-Lozano, Yue-Qi Wang et al. · Journal of Clinical Investig... · 0 citations

Review Open access Aug 2026

cGAS–STING pathway activation drives the cold-to-hot tumor transition and sensitizes immunotherapy

A detailed understanding of the cGAS-STING axis has substantial value in providing theoretical guidance and supporting clinical translation in the development of next-generation combination immunotherapies, as well as broadening the patient population benefiting from clinical interventions.

Xin-Ru Zhao, Shuai Meng, Hanzeng Cheng et al. · Cancer Biology and Medicine · 0 citations

Review Open access Aug 2026

The Significance of cGAS‐STING Signaling in Response to Oncogenic Viruses

The vital role of cGAS‐STING in the immune process is reviewed, as well as the fact that viruses causing human tumor lesions can activate cGAS‐STING, leading to virus inhibition and further preventing the occurrence and development of related cancers, and the paradoxically promoted progression of related cancers by vir...

Li-Mei Guo, Li Li, Fang Wang et al. · Cell Biochemistry and Functi... · 0 citations

Review Aug 2026

The cGAS-STING pathway and its functions in immune defense and inflammatory regulation in teleost fish.

The cGAS-STING pathway in teleost fish is systematically summarized to enhance the comprehensive understanding for the innate immune regulatory network, and the potential molecular targets is to be identified for disease-resistant breeding, immune enhancement, and sustainable aquaculture practices.

Qi-Yan Wang, Xiu-Ying Cui, M. Guo et al. · Fish and Shellfish Immunolog... · 0 citations

Open access Sep 2026

Precision tuning of STING signaling: a mutational blueprint

A comprehensive functional atlas of stimulator of interferon genes (STING) is presented, revealing how distinct structural regions of STING collectively regulate interferon induction, NF-κ B activation and non-canonical autophagy.

A. Cuapio, Hans-Gustaf Ljunggren · Signal Transduction and Targ... · 0 citations

Jul 2026

Abstract B045: Targeted degradation of cyclin T1 constrains transcription elongation and triggers tumour cell apoptosis

It is demonstrated that selective degradation of CCNT1 can effectively collapse pTEFb-dependent transcriptional programmes and compromise tumour cell fitness, which may offer a more selective and durable route for therapeutic intervention in transcriptionally dependent tumours.

Janice Wenzheng Neng, Laura Blenkarn, Laura S. Itzhaki et al. · Clinical Cancer Research · 0 citations