DNM2–Charcot–Marie–Tooth neuropathy stems from disrupted Schwann cell function and shows limited therapeutic reversibility
These findings establish the Dnm2K562E/SC− mouse as a robust preclinical model, recapitulating key features of DNM2–Charcot–Marie–Tooth, and provide crucial insight into the biological and temporal constraints that must guide future therapeutic strategies for DNM2–Charcot–Marie–Tooth.
Marie Goret, T. Arbogast, Jocelyn Laporte
· Brain Communications · 0 citations