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Author

John K. Lee

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Open access Oct 2026

tRNA dosage regulates lineage dependency and resistance in prostate cancer.

Lineage plasticity underlies therapeutic resistance in cancer1,2, yet the translational mechanisms that enable this phenotypic flexibility remain largely unknown. Here using prostate cancer as a model of lineage dependence, we performed unbiased small RNA sequencing and identified tRNA1Arg(UCU) as a regulator of lineag...

Y. Kim, Sonali Arora, D. Young et al. · 0 citations
#protein folding Open access Oct 2026

Armoring STEAP1 CAR T cells with IL-18 potentiates antitumor activity in Ewing sarcoma

Ewing sarcoma (EwS) is an aggressive malignancy of children, adolescents, and young adults driven by the EWS::FLI1 fusion oncoprotein with few effective treatment options in the relapsed or refractory setting. We validate six transmembrane epithelial antigen of the prostate 1 (STEAP1) as a fusion-regulated and clinic...

Vipul Bhatia, Annabelle Tsao, Truman Chong et al. · 0 citations

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