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Jordan Norman

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#protein folding Open access Sep 2026

Structural Plasticity and Ligand Promiscuity of CYP3A4 Revealed by Cryo-EM

Cytochrome P450 3A4 (CYP3A4) metabolizes roughly half of all marketed drugs, and its inhibition can cause clinically significant drug-drug interactions. The enzyme accommodates chemically diverse ligands, making binding modes and metabolic outcomes difficult to predict. Previous X-ray crystallography efforts have lever...

Anna K. Orta, Jan-Hannes Schäfer, G. Correy et al. · bioRxiv · 0 citations

Open access Jul 2026

Antibody reveals conformational latch regulating dimerization in β- and γ-herpesvirus proteases

Human herpesvirus (HHV) replication depends on the HHV protease (HHV Pr), an enzyme essential for capsid maturation. Because HHV Pr must transition from an inactive monomer to an active dimer, disrupting dimerization is a promising antiviral strategy. We isolate Fab5, a conformationally selective antibody from a naïve...

M. Zimanyi, Kaitlin R. Hulce, M. Bohn et al. · Nature Communications · 0 citations