Single-allele nanoscale mapping of regulatory variants.
Millions of genetic variants are linked to human disease but identifying underlying mechanisms is challenging because most variants are noncausal and lie within the noncoding genome. We developed a Micro Capture-C variant-to-function platform (MCCv) based on analysis of single-allele chromatin structure. This can ident...
Joseph C. Hamley, Wei-Jiao Zhang, Daniel Willmott et al.
· Nature Genetics · 0 citations